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Selected Publications

From a total of 120+ papers (with more than 19,000 citations)   H-index 62

Meyerson JR, Kumar J, Chittori S, Rao P, Pierson J, Bartesaghi A, Mayer ML, Subramaniam S. (2014) Structural mechanisms of glutamate receptor activation and desensitization. Nature 514: 328-334.

Zhao H, Mayer ML and Schuck P. (2014) Analysis of protein interactions with picomolar binding affinity by fluorescence-detected sedimentation velocity. Analytical Chemistry 86:3181-3187.


Zhao H, Lomash S, Glasser C, Mayer ML and Schuck P. (2013) Analysis of high-affinity self-assembly by fluorescence optical sedimentation velocity analytical ultracentrifugation of labeled proteins: Opportunities and limitations. PloS One 8:e83439.


Yao, Y., Belcher, J,. Berger, AJ., Mayer, M.L and Lau, A.Y. (2013) Conformational analysis of NMDA receptor GluN1, GluN2 and GluN3 Ligand Binding Domains Reveals Subtype Specific Characteristics. Structure 21:1788-1799.


Schauder, D., Kubeda, O, Zhang, J., Klymko, K., Batrtesaghi, A., Borgnia, M.J,. Mayer, M.L. and Subramaniam S. (2013) Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain. PNAS 110:5921-5926.


Lomash, S., Chittori, S., Brown, P.H. and Mayer, M.L. (2013) Anions Mediate Ligand Binding in Adineta vaga Glutamate Receptor Ion Channels. Structure 21:414-425.


Kumar, J. and Mayer, M.L. (2013) Functional insights from glutamate receptor ion channel structures. Annual Review of Physiology 75, 313-337.


Veran, J., Kumar, J. Pinherio, PS., Athane, A,. Mayer, M.L, Perrais, D and Mille, C. (2012) Zinc potentiates GluK3 glutamate receptor function by stabilizing the ligand binding domain dimer interface. Neuron 76, 565-578.


Zhao, H., Berger, A.J., Brown, P.H., Kumar, J., Balbo, A., May, C.A., Casillas. E., Laue, T.M., Patterson, G.H., Mayer, M.L. and Schuck, P. (2012) Analysis of high-affinity assembly for AMPA receptor amino-terminal domains. Journal of General Physiology139:371-388.

Mayer, M.L. (2011) Emerging models of glutamate receptor ion channel structure and function. Structure 19, 1370-1380.

Kumar, J. Schuck, P. Mayer, M.L. (2011) Structure and assembly mechanism for heteromeric kainate receptors. Neuron 71, 319-331.

Mayer, M.L. (2011) Structure and mechanism of glutamate receptor ion channel assembly, activation and modulation. Current Opinion in Neurobiology 21, 293-290.

Kumar, J. and Mayer, M.L. (2010) Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino terminal domains.Journal of Molecular Biology 404, 680-696.

Das. U., Kumar, J. Mayer, M.L. and Plested, A.J. (2010) Domain organization and function in GluK2 subtype kainate receptors. PNAS 107, 8463-8468.

Plested, A.J. and Mayer, M.L. (2009) AMPA receptor ligand binding domain mobility revealed by functional cross linking.Journal of Neuroscience 29, 1912-11923.

Chaudhry, C., Plested, A.J., Schuck, P. and Mayer, M.L. (2009) Energetics of glutamate receptor ligand binding domain dimer assembly is modulated by allosteric ions. PNAS 106, 12329-12334.

Kumar, J., Schuck, P., Jin, R., and Mayer, M.L. (2009) The N-terminal domain of GluR6 subtype glutamate receptor ion channels. Nature Structural & Molecular Biology 16, 631-638.

Plested, A.J. and Mayer, M.L. (2009) Engineering a high-affinity allosteric binding site for divalent cations in kainate receptors. Neuropharmacology 56, 114-120.

Chaudhry, C., Weston, M.C., Schuck, P., Rosenmund, C. and Mayer, M.L. (2009) Stability of ligand binding domain dimer assembly controls kainate receptor desensitization. EMBO J 28, 1518-1530.

Vijayan, R., Plested, A.J., Mayer, M.L. and Biggin, P.C. (2009) Selectivity and cooperativity of modulatory ions in a neurotransmitter receptor. Biophysical Journal 96, 1751-1760.

Plested, A.J., Vijayan, R., Biggin, P.C. and Mayer, M.L. (2008) Molecular Basis of Kainate Receptor Modulation by Sodium. Neuron 58, 720-735.

Yao, Y., Harrison, C,. Freddolino, P., Schulten, K. and Mayer, M.L. (2008) Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. EMBO J 27: 2158-2170.

Plested, A.J. and Mayer, M.L. (2007) Structure and Mechanism of Kainate Receptor Modulation by Anions. Neuron 53, 829-841.

Weston, M.C., Schuck, P., Ghosal, A., Rosenmund, C. and Mayer, M.L. (2006) Conformational restriction blocks glutamate receptor desensitization. Nature Structural & Molecular Biology 13:1120-1127.

Yao, Y. and Mayer, M.L. (2006) Characterization of a soluble ligand binding domain of the NMDA receptor regulatory subunit NR3A. Journal of Neuroscience 26:4559:4566.

Weston, M.C., Gertler, C., Mayer, M.L.and Rosenmund, C. (2006) Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate . Journal of Neuroscience 26:7650-7658.

Mayer, M.L. (2006) Glutamate receptors at atomic resolution. Nature 440, 456-462.

Mayer, M.L., Ghoshal. A., Dolman,N.P and Jane, D.E. (2006) Crystal Structures of the Kainate Receptor GluR5 Ligand Binding Core Dimer with Novel GluR5 Selective Antagonists. Journal of Neuroscience 26:2852:2861.

Mayer, M.L. (2005) Glutamate receptor ion channels. Current Opinion in Neurobiology 15, 282-288.

Mayer, M.L. (2005) Crystal Structures of the GluR5 and GluR6 Ligand Binding Cores: Molecular Mechanisms Underlying Kainate Receptor Selectivity. Neuron 45, 539-552.

Mayer, M.L. (2005) Some assembly required. Nature Structural & Molecular Biology 12, 208-209.

Horning, M.S. and Mayer, M.L. (2004) Regulation of AMPA receptor gating by ligand binding core dimers. Neuron 41: 379-388.

Mayer, M.L. and Armstrong, N.A. (2004) Structure and function of glutamate receptor ion channels. Annual Review of Physiology 66: 161-181.

Armstrong, N.A., Mayer, M.L., Gouaux, E. (2003) Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes, PNAS 100, 5736-5741.

Jin, R., Banke, T.G., Mayer M.L, Traynelis, S.F. and Gouaux, E. (2003) Structural basis for partial agonist action at ionotropic glutamate receptors. Nature Neuroscience 6, 803-810.

Jin, R., Horning, M., Mayer, M.L., Gouaux, E. (2002) Mechanism of activation and selectivity in a ligand-gated ion channel: structural and functional studies of GluR2 and quisqualate, Biochemistry 41, 15635-15643.

Hogner A., Kastrup J.S., Jin R., Liljefors T., Mayer M.L., Egebjerg J., Larsen I.K., Gouaux, E. (2002) Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core, Journal of Molecular Biology 322, 93-109.

Sun,Y., Olson, R., Horning, M., Mayer, M. and Gouaux, E. (2002) Mechanism of glutamate receptor desensitization, Nature 417, 245-253. (439 citations)

Panchenko, V.A., Glasser, C.R. and Mayer, M.L (2001) Structural Similarities Between Glutamate Receptor Channels and K+ Channels Examined by Scanning Mutagenesis, Journal of General Physiology 117, 345-360.

Mayer, M.L., Olsen, R. and Gouaux, E. (2001) Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state, Journal of Molecular Biology 311, 815-836.

Chen, G.Q, Cui, C., Mayer, M.L and Gouaux, E. (1999) Functional characterization of a potassium-selective prokaryotic glutamate receptor, Nature 402, 817-821.

Cui, C. and Mayer, M.L. (1999) Heteromeric Kainate Receptors Formed by Coassembly of GluR5 GluR6 and GluR7, Journal of Neuroscience 19, 8281-8291.

Partin, K.M., Fleck, M. and Mayer, M.L. (1996) AMPA receptor flip/flop mutants affecting deactivation, desensitization, and modulation by cyclothiazide, aniracetam, and thiocyanate, Journal of Neuroscience 16, 6634-6647.

Bowie, D. and Mayer, M.L. (1995) Inward Rectification of Both AMPA and Kainate Subtype Glutamate Receptors by Intracellular Polyamine Mediated Ion Channel Block, Neuron 15, 453-462. (346 citations)


Partin, K.M., Bowie, D. and Mayer, M.L. (1995) Structural determinants of allosteric regulation in alternatively spliced AMPA receptors, Neuron 14, 833-843 (127 citations)

Partin, K.M., Patneau, D.K. and Mayer, M.L. (1995) Cyclothiazide Differentially Modulates Desensitization of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Splice Variants, Molecular Pharmacology 46, 129-138 (245 citations)

Patneau, D.K., Mayer, M.L. and Gallo, V. (1994) Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor, Neuron 12, 357-371. (250 citations)

McBain, C.J. and Mayer, M.L. (1994) N-Methyl-D-Aspartic acid receptor structure and function., Physiological Reviews 74, 723-760. (741 citations)

Partin, K., Patneau, D.K., Winters, C.A., Mayer, M.L. and Buonanno, A. (1993) Selective Modulation of Desensitization at AMPA versus Kainate Receptors by Cyclothiazide and Concanavalin A, Neuron 11, 1069-1082 (478 citations)

Wong, L.A. and Mayer, M.L. (1993) Differential Modulation by Cyclothiazide and Concanavalin A of of Desensitization at Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid_Preferring versus Kainate-Preferring Glutamate Receptors, Molecular Pharmacology 44, 504-510 (178 citations)

Patneau, D.K., Vyklicky, L., and Mayer, M.L. (1993).  Hippocampal-Neurons Exhibit Cyclothiazide-Sensitive Rapidly Desensitizing Responses to Kainate. Journal of Neuroscience 13, 3496-3509 (333 citations)

Vyklicky, L., Patneau, D.K. and Mayer, M.L. (1991) Modulation of Excitatory Synaptic Transmission by Drugs which Reduce Desensitization at AMPA/Kainate Receptors, Neuron 7, 971-984 (211 citations)

Patneau, D.K. and Mayer, M.L. (1991) Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons, Neuron 6, 785-798 (220 citations)

Benveniste, M. and Mayer, M.L. (1990) Kinetic-Analysis Of Antagonist Action At N-Methyl-D-Aspartic Acid Receptors - 2 Binding-Sites Each For Glutamate And Glycine. Biophysical J ournal 59, 560-573 (131 citations)

Patneau, D.K. and Mayer, M.L. (1990) Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. Journal of Neuroscience 10, 2385-2399 (488 citations)

Mayer, M.L., Vyklicky, L. and Clements, J.D. (1989) Glycine regulates NMDA receptor desensitization in mouse hippocampal neurones. Nature 338, 425-427 (351 citations)

Sernagor, E., Kuhn, D., Vyklicky, L. and Mayer, M.L. (1989) Open channel block of NMDA receptor responses evoked by Tricyclic antidepressants. Neuron 2, 1221-1227 (102 citations)

Mayer, M.L. and Vyklicky, Jr. L. (1989) Concanavalin-A selectively reduces desensitization of mammalian neuronal quisqualate receptors, PNAS 86, 1411-1415. (222 citations)

Mayer, M.L. and Westbrook, G.L (1987) The physiology of excitatory amino acids in the vertebrate central nervous system. Progress in Neurobiology 28, 197-276. (1548 citations)

Mayer, M.L. and Westbrook, G.L (1987) Permeation and block of N-methyl-D-aspartate receptors by divalent cations in mouse cultured hippocampal neurons. Journal of Physiology 394, 501-527. (752 citations)

Westbrook, G.L. and Mayer, M.L. (1987) Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of central neurons. Nature 328, 640-643. (760 citations)

MacDermott, A.B., Mayer, M.L., Westbrook, G.L., Smith, S.J. and Barker, J.L. (1986) NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321, 519-522. (1415 citations)

Mayer, M.L. and Westbrook, G.L (1985) The action of NMDAon mouse spinal neurones in culture. Journal of Physiology 361, 65-90. (391 citations)

Mayer, M.L. (1985) A calcium-activated chloride current generates the after-depolarization of rat sensory neurones in culture. Journal of Physiology 364, 217-239. (222 citations)

Mayer, M.L., Westbrook, G.L. and Guthrie, P.B. (1984) Voltage dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309, 261-263. (2090 citations)

Mayer, M.L. and Westbrook, G.L (1983) A voltage-clamp analysis of inward (anomalous) rectification in mouse spinal sensory ganglion neurones. Journal of Physiology 340, 19-45. (404 citations)


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